3 Supplements That Increase Nerve Growth Factor In Your Brain #Memory

by admin on September 9, 2014

What Is Nerve Growth Factor?

nerve growth factor supplement

Brain Cells Before (left) and After (right) Nerve Growth Factor Exposure

Nerve growth factor is a small protein that is secreted for the purpose of growth, maintenance and survival of nerve cells. NGF also is important in message signaling between nerve and as a result is vital for optimal cognitive function. The brain is made up of about 100 billion nerve cells, which communicate to each other.

Though Nerve Growth Factor DOES regenerate new brain cells (neurogenesis) over time, NGF also immediately increases the brains cognitive function by enhancing nerve signaling. 

Think of the development stage between the time you were a fetus all the way through adulthood. What is it that caused the development and growth of all these nerves? Indeed it is NGF that is responsible for the growth and generation of the brain and the entire nervous system.

Once the brain and remaining nervous system is fully developed, NGF production sharply declines. This leaves us vulnerable to an inevitable degeneration of the central (brain/spinal cord) and peripheral (nerves through the rest of the body) nervous systems through adulthood. A degeneration or lack of proper development of this system of the body certainly contributes to dementia, multiple sclerosis, depression, schizophrenia, autism, anorexia and bulimia nervosa, among other diseases.

This results in a decline of brain function with age and a decline in quality of life (QOL). QOL decreases drastically because we experience our existence through our nervous systems. Our nervous systems comprise all of our senses and thought processes. Without your nervous system to sense and think, you would have no human experience here on earth. This is why the nervous system is the major human system that I care for above all other systems of my body.

So what can be done about the degeneration of the nervous system? Can nerve growth factor production be returned to youthful levels? Believe it or not, there are foods and nutrients on this planet which, when consumed, drastically increase nerve growth factor production in the body and brain. This is extremely powerful because even an injection of pure NGF will not benefit the brain. This is because it cannot cross the blood-brain barrier. NGF must be created inside the brain in order to regenerate the brain.

This is why “natural” is the only way to go with NGF. We must feed the body in a way that will cause the brain and nervous system to produce an abundance of NGF. This will result in a maintenance and even regeneration of the nerves throughout the body, regardless of age.

Foods And Supplements To Increase NGF

There are plenty of studies showing certain individual nutritional supplements to significantly increase nerve growth factor production in the body. If one was to combine all of these well studied supplements and consistently consume them into old age, the long term results would be dramatically beneficial in terms of brain function and quality of life.

In the central nervous system, benefits would be experienced in working and spatial memory (enhanced double tasking), reduced anxiety/depression and increased learning capacity. In the peripheral nervous system, conditions benefited would include multiple sclerosis, diabetic neuropathy as well as any condition where the nerves of the body have been damaged, chronic or acute trauma.

Now that we understand the role of nerve growth factor, let us look at the top 3 brain food/supplements that have been well studied stimulate the production of NGF in the human brain.


1. Lion’s Mane Mushroom (<–Click Name For Lion’s Mane Capsules)OLYMPUS DIGITAL CAMERA

If you were walking in the forest and stumbled upon a Lion’s Mane Mushroom, you would have to guess that aliens visited and left an nest of eggs. Though it looks alien, Lion’s Mane is an Earthling that belongs in the toothed fungus group. A mature Lion’s Mane Mushroom also looks similar to a brain, nature never fails to hint at what foods to use to heal which ever body part we need healed.

Lion’s Mane is botanically known as hericium erinacius. Lion’s Mane, though relatively unknown to most modern people, was one of the most treasured edible and medicinal mushrooms to ancient peoples. The lion’s Mane Mushroom is my personal favorite food specific to brain function and regeneration as it is thoroughly studied to stimulate nerve growth factor production in humans when consumed.


The Lion’s Mane is the most well studied neuro-regenerative botanical of modern science. Research of Lion’s Mane Mushroom supplementation has demonstrated the following:

– Stimulated growth of animal nerve cells (1)

– A well controlled study demonstrated increased cognitive abilities is subjects suffering from mild cognitive impairment (2)

– A compound called Hericenone, derived from Lion’s Mane, stimulated the production of nerve growth factor in human astrocytoma cells  (3)

– Stimulated nerve myelination in an in vitro experiment (4) Nerve myelination is the electrical insulation of nerve cells which allows for strong and accurate nerve message signaling. Increasing myelination increases nerve function

– Regenerated peripheral nerves after crush injury was applied (5)

These studies demonstrate a guaranteed regeneration of nerves through stimulation of nerve growth factor. Though improvement in cognition is seen within days, cognitive effects of Lion’s Mane really shine after at least 6 months of continued regeneration through supplementation.

2. Ashitaba (<–Click Name For Capsules)(Ashitaba Keiskei)

nerve growth factor supplement

Cut Ashitaba stem heals itself with yellow NGF stimulating calchone fluid. Notice the new leaves rapidly regenerating, thus the nickname “Tommorow Leaf”.

This is a plant native to Japan which has been used as a longevity tonic for at least 2,000 years. This plant has extremely rare flavonoid antioxidants in it called chalcones. Chalcones, in nature, are not found outside of the angelica family of plants, which ashitaba is a part of.

One study showed a 20% increase in nerve growth factor after just four days of ashitaba consumption. Though it is not yet completely understood exactly how ashitaba stimulates nerve growth factor in humans, studies have demonstrated this rare effect and this cannot be ignored.

I have no idea how ashitaba hasn’t been getting more attention in the anti-aging/herbalism world. It is one of the most regenerative, healing and anti-aging herbs I have ever learned about and yet nobody has ever heard of it. For sure stay ahead of the curve and get on ashitaba.

Ashitaba is classified as a rare adaptogenic plant. If you do not know about adaptogenic herbs, they are the most powerful longevity medicines yet discovered on Earth. The longevity benefits of adaptogens come from their intelligent abillity to “modulate” the systems of the body and desensitize all cells in the body to any source of stress. Essentially, all adaptogens regulate the body and sheild it against the damaging effects of any environmental stressors. combining all of these factors, ashitaba is one of my top anti-aging herbs. To learn more about ashitaba’s benefits, check out this article.

3. Acetyl-L-Carnitine Arginate + Acetyl-L-Carnitine (<–Click Link For Capsules)nerve growth factor supplement

Carnitine is a dipeptide naturally found in the human body that plays an important role in nerve health. While this does not technically stimulate nerve growth factor, this combination of carnitine analogues has been studied to mimic NGF in the brain, providing the same benefits of nerve growth, in some ways even more. One study showed us that acetyl-l-carnitine stimulates the creation NGF receptors in the brain (multiplying the effects of existing NGF) while acetyl-l-carnitine arginate mimics NGF in the brains, combining to provide extremely powerful neurotrophic effects in nervous tissue. (6)

Carnitine + carnitine arginate’s studied synergistic effect on neural outgrowth is impressive on its own. When combined with natural NGF stimulators such as Lion’s Mane and Ashitaba, the neurotrophic effects are beyond significant.


There are other nerve supplements that could be mentioned but these are certainly the most promising and powerful supplements in field of neurogenesis right now. I wanted to share the very best with you. The combination of these three will serve as an extremely effective nerve growth stimulator and long term brain tonic to increace and enhance all fields of cognitive performance and enjoyment.

Additional Tips

When taking lion’s mane mushroom, or any other medicinal mushroom, always take it with at least a small dosage of vitamin C. This drastically enhances the absorption of mushrooms and most other supplements as well. Another option for increasing absorption would be consuming a proteolytic enzyme like bromelain. Consuming bromelain comes with its own dramatic healing and anti aging benefits. Increasing absorption is vital to get your dollars worth out of you supplements.
One more tip – for greatest benefit, take these and all supplements 3-5 times throughout the day. This insures that you always have the active compounds in your bloodstream. This is an especially important tip if you usually consume a handful of supplements once or twice a day. Spreading it out more evenly will increase absorption as well as time of exposure to the therapeutic compounds.



1. Park, Y. S.; Lee, H. S.; Won, M. H.; Lee, J. H.; Lee, S. Y.; Lee, H. Y. (2002). “Effect of an exo-polysaccharide from the culture broth of Hericium erinaceus on enhancement of growth and differentiation of rat adrenal nerve cells”. Cytotechnology 39 (3): 155–162. doi:10.1023/A:1023963509393. PMC 3449638. PMID 19003308

2. Mori, K.; Inatomi, S.; Ouchi, K.; Azumi, Y.; Tuchida, T. (2009). “Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial”. Phytotherapy Research 23 (3): 367–372. doi:10.1002/ptr.2634. PMID 18844328

3. Bioactive Substances in YAMABUSHITAKE, the Hericium erinaceum, Fungus, and its Medicinal Utilization, Takashi Mizuno, Shizuoka University.

4. Kolotushkina, E. V.; Moldavan, M. G.; Voronin, K. Y.; Skibo, G. G. (2003). “The influence of Hericium erinaceus extract on myelination process in vitro”. Fiziolohichnyi zhurnal 49 (1): 38–45. PMID 12675022

5. Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae), Kah-Hui Wong, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia.

6. Tagliatatela G, Angelucci L, Ramacci MT, Werrbach-Perez K, et al. Acetyl-L-carnitine enhances the response of PC-12 cells to nerve growth factor. Brain Res Dev Brain Res. 1991 Apr 24;59(2):221-30.

{ 13 comments… read them below or add one }

peter December 14, 2014 at 1:00 pm

Hey where can you find all these together


Michelle December 20, 2014 at 1:50 pm

Where do you find these items?


tim January 16, 2015 at 9:33 pm

Thank you for this awsome info. I read it all. Vit C with mushroom supplements..more adsorption 🙂


admin February 23, 2015 at 9:59 pm

Click on the name of any of the 3 supplements, the link is to amazon where you can find all 3. Click the link of each individual name to go to the specific supplement that I recommend.


Sam Begum April 21, 2015 at 6:03 pm

Thanks love the info informative and hopefully life changing



Chet July 11, 2015 at 10:53 am

I read elsewhere that higher levels of NGF are correlated to feelings of being “in love.” Have you experienced this personally? Just curious.


admin July 22, 2015 at 10:51 pm

I read this as well, it seems that NGF increases during the infatuation phase of the relationship. Perhaps the brain is rewiring in order to strengthen and more deeply layer the relationship you share with your mate..


Marko July 12, 2015 at 6:55 am

Lion’s Mane works like a magic pill with me. I’m thinking to add Acetyl-L-Carnitine to the stack… What are your personal experiences with Acetyl-L-Carnitine?


admin July 22, 2015 at 10:55 pm

I have used it, especially in my martial arts training. I find it to be a good supplement for athletics and a great supplement for brain health.


Nathan July 18, 2015 at 6:35 am

“One study showed a 20% increase in nerve growth factor after just four days of ashitaba consumption.”
Do you have the reference to this study? Can’t seem to find it.

Regards, Nathan.


Sam August 1, 2015 at 8:57 am

I cannot find anything about Ashitaba in your references, and when I search for Ashitaba+NGF or Ashitaba+Neuron in google scholar, nothing relevant comes up.


bina October 24, 2016 at 6:31 am

Can I use these herbal madicen for my 2 year baby how much dose should I give.he have thin optic nerve and pale rise.kindly guide me


sarah reeve January 24, 2017 at 2:34 pm

Hi, would any of these be suitable for equine consumption? I have a mare with dysphagia caused by a fungal infection that attach the Vagus nerve.


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